Recent Funded Projects


RECENT FUNDED PROJECTS

An informatics framework for SUDEP risk marker identification and risk assessment

Project Number:1R01NS116287-01 / Project Start Date: May-2020

Funding institute and center: National institute of neurological disorders and stroke

PI: Licong Cui, PhD

The main goal of this project is to develop an informatics approach for automated extraction of SUDEP risk markers from multimodal clinical data to enable individualized SUDEP risk assessment. Success of this study will enable systematic SUDEP risk assessment based on known and putative factors and communication of such risk factors to patients with epilepsy. Ultimately, this study can lead to evidence-based SUDEP risk assessment tools that help clinicians and patients manage potentially modifiable risks, leading to overall reduced SUDEP mortality and improved epilepsy patient care.

 

 

The role of central CO2 chemosensitivity in postictal respiratory depression and SUDEP

Project Number:1R01NS113764-01 / Project Start Date: SEP-2019 

Funding institute and center: National institute of neurological disorders and stroke

PI: George B Richerson, MD, PhD

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. In many cases, death follows a period of severe seizure-induced respiratory depression, for which the cause is not understood. The proposed research is relevant to public health and the NIH’s mission because a better understanding of the role played by central CO2 chemosensation in the pathogenesis of seizure-induced respiratory depression is expected to lead to the identification of novel candidate biomarkers for SUDEP risk and to the development of new preventive treatments for SUDEP.

 

 

Isolating SUDEP risk conferred by genomic co-variation in candidate SUDEP genes

Project Number: 1R21NS113015-01 / Project Start Date: JULY-2019 

Funding institute and center: National institute of neurological disorders and stroke

PI: Alica Goldman, MD, PhD

Aims: This pilot project aims to evaluate the components of genetic risk in SUDEP in SCN1A gene related epilepsy and in patients with febrile seizure phenotype. Goal of this project is to develop critically needed bioinformatic tools for genomic SUDEP risk stratification. Results will have an immediate impact on patients with epilepsy due to SCN1A gene pathogenic variation and they will inform future bioinformatics and statistical design when analyzing SUDEP risk in patients with the clinically very common febrile seizure phenotype as well as when evaluating causality in existing collections of SUDEP cases.